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October 4, 2011 • Page 9
Sudden infant death syndrome (SIDS) can be a
devastating blow to new parents. Seemingly out of nowhere
an infant can lose his or her life. Although SIDS research is
ongoing, recent research suggests a link between SIDS and
serotonin deficiency.
SIDS remains the leading cause of death for children
age one month to one year. Although the rate of fatalities
has decreased over the last two decades, no doubt because of
increased awareness, there are still some babies who perish
despite parents doing everything right in the infant’s
environment. This could leave people to believe there might
be a biological factor at play as well.
Recently, a team led by a Children’s Hospital Boston
neuropathologist pinpointed a defect in the brain that could
be responsible for some cases of SIDS. The findings were
published in the Journal of the American Medical
Association in early 2010. The team studied the brainstems
of 41 children who had died from SIDS; the brainstems of
seven children who died of other causes; and the brainstems
of four children who died after being treated for low oxygen
levels, a condition thought to contribute to SIDS. The
brainstem is the part of the brain that regulates blood flow,
controls breathing, regulates body temperature, and controls
sleeping and waking.
When the comparison was done, the research team
found serotonin levels in 25 of the 41 SIDSinfants were 26
percent lower than the levels in the children who had died
from other causes. There was also a 22 percent deficiency in
another enzyme that stimulates serotonin production.
Binding to serotonin receptors was 50 percent lower in the
SIDS babies.
Serotonin is a neurotransmitter, a substance that is
designed to transmit messages from one nerve cell to
another in the central nervous system. Low levels of
serotonin can lead to depression, sleep disorders and various
forms of addiction. Serotonin affects and controls mental and
emotional processes, some motor functions,
thermoregulation (temperature control), regulation of blood
pressure, and some hormonal functions. Serotonin also plays
an important role in the onset of sleep.
SIDS is a term medical professionals and scientists use
to describe the unexplained death of a child under the age of
one. In the past, SIDS was known as “crib death” because
parents would put their child in a crib and return to find the
child had passed away.
Although scientists are still trying to unlock potential
biological factors in SIDS, doctors recommend controlling
the environmental and physical factors that may contribute.
These factors include:
• mothers avoiding drugs, alcohol and cigarettes while
pregnant;
• keeping the house smoke-free after the baby is born;
• ensuring the infant is not overheated in his or her
crib;
• placing the baby to sleep on his or her back;
• keeping the crib free of breathing obstructions, such as
pillows, heavy bedding or stuffed animals;
• maintaining routine well visits with a pediatrician;
and
•having the infant sleep close to mom or dad (but not in
the same bed) so that breathing can be monitored.
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New SIDS research
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